Key Features

  • Over 150 different GPCR functional cell lines
  • Customized GPCR stable cell line construction
  • Multiple assay formats including calcium flux, cAMP determination, and Luciferase reporter gene assays
  • Determine drug potency and efficacy in agonist, antagonist, inverse agonist and allosteric modulator modes
  • Stringent QC standards with competitive prices
  • Short turnaround time

More strategies to facilitate new drug development

GenScript ProBio offers multiple functional assays to characterize your samples for agonist, inverse agonist, antagonist and allosteric modulator activities.

  • 检测实验
  • No. Part of GPCR cell lines
    1CHO-K1/ADRA1A
    2CHO-K1/MC3/Gα15
    3CHO-K1/ADORA2A/Gα15
    41321N1/P2Y1
    5CHO-K1/5-HT2A
    6CHO-K1/5-HT2C
    71321N1/P2Y12/Gα15
    8CHO-K1/OPRK1/Gα15
    91321N1/P2Y4
    101321N1/P2Y11
    11CHO-K1/OPRM1/Gα15
    12CHO-K1/OPRD1/Gα15
    13CHO-K1/ADORA1/Gα15
    14CHO-K1/ADORA2B/Gα15
    15CHO-K1/5-HT1A/Gα15
    16CHO-K1/5-HT4/Gα15
    17CHO-K1/OPRL1/Gα15
    18CHO-K1/GLP1/Gα15
    19CHO-K1/ADORA3/Gα15
    20CHO-K1 /CXCR1/Gα15

Case Study

GPCR overexpression cell line facilitates new drug development

The expression level of GPCR in vivo is low and the effect of conventional overexpression is not sufficient, which is not conducive to the study of GPCR structure and function. With protein engineering and sequence optimization, we are able to significantly increase the expression level of ADORA2A protein on the cell surface.

检测实验