CHOK1-GenS
Cell Line Development System Commercial License

GenScript ProBio is now licensing the CHOK1-GenS cell line development system to biopharma companies for commercial use. Contact us for more information!

GenScript ProBio has 12 years of experience in mammalian cell line development, and is one of the earliest companies getting the CHO-K1 commercial use license and sublicense agreement from ECACC.

After serum-free suspension adaption and characterization, GenScript ProBio acquires the host cell for CHOK1-GenS cell line development system without chemical modification. In together with the high-expression proprietary pGenHT 1.0-DGV vector, the yield titer can reach an average of 4.35g/L , up to 8.70g/L

GenScript ProBio is experienced with 300+ cell line development projects, and the CHOK1-GenS system has been used in 30+ CMC&CMO projects in which 5 has got IND approvals.

CHOK1-GenS system exclusive advantages

High productivity with CHOK1-GenS system

• High antibody titer - average titer: 4.35g/L, up to 8.70g/L

  

• Suitable for different type of molecules

  

Excellent stability with CHOK1-GenS system

• No.	Type	Study period	T1（g/L)	Titer variation
  1	IgG 1	PCB-60days	3.43	-9.90%
  2	IgG 1	PCB-60days	3.54	-7.00%
  3	IgG 4	PCB-50days	3.15	-9.00%
  4	IgG 4	PCB-60days	3.63	-8.20%
  5	IgG 4	PCB-60days	4.23	-10.40%
  6	Bispecific mab	PCB-60days	2.72	-3.40%
  7	IgG 1	PCB-60days	4.68	-22.22%
  8	IgG 1	PCB-96days	4.76	-23.39%
  9	Protein	PCB-50days	1.91	-11.52%
  10	IgG 1	PCB-60days	6.37	-4.55%
  11	tri-specific ab	PCB-50days	0.34	-17.60%
  12	IgG 1	WCB-50days	3.78	-24.60%
  13	IgG 1	WCB-50days	5.74	-20.55%

• • The titer at the end of stability study during fed-batch is recorded as T2.
  • The titer at the beginning of stability study during fed-batch is recorded as T1.
  • Titer variation=(T2-T1)/T1*100%
  • Titer variation should be within 30%.
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High productivity with CHOK1-GenS system

• Titer prior to cell culture up to 8.70 g/L

  
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• Excellent Stability in Scale-Up from 3L to 200L

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CHOK1-GenS delivery package