Wide range of cost-efficient, high throughput assays
Over 240 human tumor cell lines, including in vivo validated xenograft cell lines
Oncology drug discovery requires knowing the pharmacological mechanism, and efficacy of small molecules on human tumor cell lines. GenScript ProBio offers a comprehensive oncology drug discovery platform which includes antibody drug discovery, in vitro and in vivo pharmacology services. As part of our in vitro oncology services, the cost-efficient human tumor cell line profiling packages, OncoProfiler and XenoProfiler, provide you with a combined panel of over 240 human tumor cell lines as well as a range of high throughput screening (HTS) options. XenoProfiler is a panel of tumor cell lines that have been validated in vivo with xenograft models. Together, OncoProfiler and XenoProfiler not only provides efficacy data in human tumor cell lines, but can ensure translation of efficacy from in vitro to in vivo models.
As a fully custom service, we offer a wide range of assays to use for proliferation and apoptosis profiles. Additionally, we offer biomarker, cytokine induction and combinatorial drug effect screening.
Dose response IC50 of three compounds are reported in the above graph against 225 different human tumor cell lines. Luminescence-based proliferation assay was used to profile compound effect.
Doxorubicin was used as an internal reference compound. Shown above is the IC50 of doxorubicin on proliferation of BEL-7402 cells.
Doxorubicin dose response on inhibition of proliferation of BEL-7402 is shown above.
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