Field of Application
Cell proliferation assays are widely used and accepted in oncology for drug testing when transitioning from biochemical screening to constructing biologically relevant models.
GenScript Probio offers a comprehensive oncology drug discovery platform which includes antibody drug discovery, in vitro and in vivo pharmacology services. As part of our in vitro oncology services, the cost-efficient human tumor cell line profiling can provide you with a panel of over 200 human tumor cell lines as well as a range of high throughput screening (HTS) options.
Key Features of Tumor Profiling Service
- High reproducibility and short turnaround time
- Over 200 human tumor cell lines available
- High throughput screening (HTS) options available
- Experienced customization services
Tumor cell line panel
Distribution of tumor types in the service
Tumor Cell Line List
Please download the tumor cell line list for your reference
Tumor Cell Line Profiling Assay
As a customized service, we offer a range of assays for proliferation and apoptosis profiles. Additionally, we offer cytokine induction and combinatorial drug effect screening.
| Profile | Assay Description | Throughput |
|---|---|---|
| Proliferatione | Luminescent cell viability assay | 384-well |
| Cell Counting Kit-8 (CCK-8) assay | 96-well | |
| Cytokine induction | Luminescent cell viability assay | 96-well |
| Combinatorial drug effect | Luminescent cell viability assay | 96-well |
Track Records
Case study: Analysis of proliferation inhibition
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Dose response IC50 of three compounds are shown in the graph below against 225 different human tumor cell lines.
Figure 1: Profiles of three compound effect on proliferation of 225 tumor cell lines
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Doxorubicin was used as an internal reference compound. Shown above is the IC50 of doxorubicin on proliferation of BEL-7402 cells.
Figure 2: Data reproducibility confirmed across plates for doxorubicin against BEL-7402 cell proliferation
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The internal control Doxorubicin dose response on inhibition of proliferation of BEL-7402 is shown below.
Figure 3: A collection of dose response data on the effect of doxorubicin on BEL-7402 cell proliferation