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Anti-idiotype Antibody Services

14 years' experience with over 400 Projects

Guarantee application in immunoassay development for PK and ADA analysis

New upgraded

Upgraded! Anti-idiotype Antibody Services

An anti-idiotype antibody (anti-ID Ab, see the schematic diagram) binds to the idiotype of another antibody, usually an antibody drug. An idiotype can be defined as the specific combination of idiotopes present within an antibodies complement determining regions. Since anti-ID Abs are capable of binding to antibody drugs within biological fluids, they are commonly used in preclinical setting for antibody drug pharmacokinetics (PK) and pharmacodynamics (PD). Due to the similarity between anti-ID Abs and anti-drug antibodies, anti-ID Abs are also commonly used as a reference standard for antibody drug immunogenicity, anti-drug antibody (ADA) studies.

GenScript has 14 years experience in developing of highly sensitive and specific polyclonal and monoclonal anti-ID Abs to support your antibody drug development. We try to work as closely as possible with our customers to understand their specific downstream application in order to generate their perfect anti-ID. See our case studies »

Anti-Idiotype Antibodies

Type 1. Antigen-blocking 2. Non-blocking 3. Complex-specific
Schematic diagram
Feature Paratope-specific Not Paratope-specific Partially paratope-specific
Antigen binding Inhibitory Not inhibitory Not inhibitory
Application Detect free drug only Detect total drug (free and bound) Detect bound drug typically
Selection Guideline
  • Type 1 or type 2 could be applied to detect antibody drug when having a cell-bound drug target e.g. PD1/PDL1
  • Type 1 & type 2 may both be needed when having a secret drug target e.g. TNF

Features of GenScript Anti-ID Antibodies Service

  • Application tailored anti-id mAb

    Fit for capture ELISA & sandwich ELISA

  • Fast delivery

    8 weeks to delivery purified Anti-id pAb with guaranteed quantity

  • High success rate

    100% for blocking anti-id Ab

Anti-ID Package Details

Typical Application Starting material Turnaround time (weeks) Deliverable

Positive control for ADA mensuration

  • ≥ 45 mg Target antibody drug (customer provide, purity > 85%)
  • ≥ 30 mg Isotype control-human IgG (GenScript provide, purity > 90%)
  • Human IgG1: 8-10
  • Human IgG2/IgG4: 10-12
  • Other Type#: >13
  • Small scale affinity purification after 2rd immunization for in-house detection (optional)
  • Affinity purified pAb (at least 5 mg)
  • COA report
  • Pilot sensitivity report (optional)

QC standard: ELISA titer ≥ 1: 243,000; cross rate ≤ 2%

#Other type: including but not limited to peptide, protein, ADC, SvFv & bispecific antibody.

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