Process development for triple transfection
Support regulatory filing
AAV vector is widely used delivery vehicle for gene therapy due to its high safety and effectiveness in delivering Gene of Interest (GOI). GenScript ProBio is broadening its business in AAV services to cater to the market demand.
GenScript ProBio offers services from cell banking, process development, analytical development, to GMP manufacturing and stability test for AAV vector. We are also ready to prepare reports and documents to support the regulatory filings.
GenScript ProBio is also able to produce AAV plasmids to take care of your projects from plasmids to AAV.
Among the various ways of producing AAV vector, the most mature, versatile and cost-effective one is triple transient transfection system. Three plasmids, helper plasmid, Rep/Cap plasmid and AAV transfer plasmid, are co-transfected in packaging cell line, such as HEK 293, to manufacture AAV.
Professional team averagely over 10 years of virus production experience
Process development for specific project based on platform experience
ddPCR for titer measurementAUC for full ratio measurement
Strict product release criteriaDocument preparation for regulatory filing