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Developing high-producing and robust processes

Comprehensive upstream process, downstream
process, and analytical development

Process Development Services

With team of experienced scientists and proprietary development platform, GenScript provides custom services for upstream process development, ranging from optimizing cell growth, screening production media, defining feeding strategies, to studying clone stability, and further scale-up to pilot and commercial production. We also offer a thorough analysis of growth rate, subcultivation ratios, cell mass, and other parameters. Upon request, we can perform additional specific process optimization studies or employ our scaled-down models to predict cell performance.

GenScript offers services for purification process development. For downstream process, protein purification is typically conducted through affinity columns. We also offer other chromatographic methods including gel filtration, ion exchange, and hydrophobic interactions. The purification tags are removed via a specific protease if desired, and the protein is further purified by gel filtration.

Stable cell line development

GenScript is proud of offering its years of demonstrative and professional custom services in generation and selection of stable clones for protein production.

  • Proprietary OptimumGene codon optimization technology significantly increased expression level in any system.
  • Reliable DHFR system, used for many commercial products.
  • Professional high-throughput screening platform.
  • Strict protein expression stability and growth stability evaluation.

Upstream process development

Professional technology and strict process control ensures the high productivity of the developed processes, and the robustness of the processes during scale-up.

  • High-throughput cell culture media and feed screening and optimization
  • Bioreactor control strategy design and lock-in
  • Process parameters and product quality attributes optimization
  • Robust process scale-up

Downstream process development

Combinations of various optimized methods conditions to ensure the maximum target protein quantity and high protein quality.

  • Purification process development
  • Protein modification process development
  • Analytical assay development

Quotations and Ordering

To request a quotation, please contact us via our toll-free phone, email, fax, or our secure online messaging system. Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.