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ProAAV Manufacturing Service

Triple Transient Transfection System

Cost-effective option for non-clinical phases

ProAAV Manufacturing Service

GenScript ProBio offers ProAAV manufacturing services suitable for the use in non-clinical phases , such as animal studies on primates, or toxicology studies, etc.

We follow the phase-appropriate compliance, to guarantee the safety of the products in the use of non-clinical phases, while reducing time and saving cost.

We are also experienced and dedicated to producing plasmid DNA of different grades for packaging AAV Vector.

Overview of ProAAV Manufacturing Workflow

GenScript ProBio manufactures AAV Vector using triple transient transfection with suspension production system, with a manufacturing scale up to 50L. After deeply studying and optimizing the upstream and downstream CPP (Critical Process Parameter), we have developed a stable and robust AAV manufacturing process.

Characteristics of ProAAV Manufacturing

We follow the phase-appropriate compliance, and set standards for the production of ProAAV with respect to manufacturing environment, appropriate QC items and standards, and quality assurance process, to guarantee the safety of the products in the use of non-clinical phases, while reducing time and saving cost.

  • ProAAV Characteristics

    • Starting from RCB (MCB optional)
    • HEK 293
    • Non-disposable materials (optional)
    • RoA file
    • Manufacturing Summary report
    • Personnel training
    • ......
  • ProAAV Quality Control Items

    • Full/empty ratio – AUC
    • Physical titer – ddPCR
    • Identification
    • Purity
    • Residual host cell protein
    • Residual host cell DNA
    • Residual plasmid
    • Sterility
    • Endotoxin
    • ......

With a solid understanding of the requirements in non-clinical phases, GenScript ProBio is the best partner to suffice your needs

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