Skip the generation of anti-idiotype antibodies
Acquire universal PK tool antibodies in one week
Anti-idiotype antibodies(Anti-ID Abs) are commonly used in pharmacokinetic (PK) analysis of antibody drugs , but it usually takes 6 months in advance in antibody generation, which is the rate limiting step in drug development. GenScript ProBio successfully developed a panel of universal PK tool antibody for PK testing before IND in mAb and ADC drugs, it will accelerate your preclinical study by skipping the generation of anti-idiotype antibody.
This antibody panel contains more than ten pairs of anti-human IgG antibodies, which can specifically recognize human Fc, and have good performance in sensitivity, specificity and accuracy for PK testing in discovery and preclinical stage . You can acquire those Ab pairs in 1 week from ProBio.
Universal PK Tool Antibody Panel for Antibody Drug:
Those universal antibodies are validated in different matrixes (mouse/rat/dog/cyno), and could be bound and paired to more than 30 antibody drugs(mAb, ADC) in IgG1, IgG2, IgG4 subtypes.
Universal PK Tool Antibody for Antibody Drug
Fast Turn Around Time
Get it antibody pairs as fast as 1 week
Cost is a fraction of Anti-ID Abs
Provide PK kit development and production services
GenScript ProBio can provide you with paired antibody screening services. You only need to provide targeted antibody drugs, and you can get guaranteed paired antibodies for PK methodology development as soon as 1 week.
*If no binders are identified after screening, the project will be terminated and 20% price of milestone 1 will be charged.
You can select interested antibodies to purchase in the universal PK tool panel and do not have to pay for binding services fee. Welcome to contact us for more service details.
GenScript ProBio can establish a universal Sandwich ELISA detection method for the Fc fragment for you, and provide high-quality and high-stability kit development and production services.
These antibodies were validated to bind and pair with multiple antibody drugs (mAb, ADC) with the IgG1, IgG2, IgG4 subtype
These antibodies don't have cross-reaction with IgG of various species like mouse, rat, dog and cyno.>/p>
The success rate of immunoassay development could largely increase when using Sandwich ELISA to select universal PK antibody pair.
As it was shown in the table, mAb17 and mAb17 are able to pair with mAb4 and mAb5.
The standard curve was demonstrated to be consistent by three independent experiments.
The standard curve can be well established in the influence of the matrix of four animal models
As it was shown in the table, the mean of LOD is 0.0107ng/mL and show great sensitivity
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