Home » Biologics CDMO » Host Cell Commercial License
  • 110+ IND-Enabling Projects

  • 21 IND Filings Supported

By Nov.2022

CHOK1 system exclusive advantages

IP Clear

√ ECACC license agreement
√ Proprietary pGenHT 1.0-DGV vector

Royalty Free

√ One-time payment without royalty

2 CHO-K1 Host Cell License to Choose

√ Wide type CHOK1-GenS
√ ADCC enhanced CHOK1-ADCC+

Combo license at discounted price

√ Purchase in combination with wild type CHOK1-GenS cell line, and get a discounted price

Suitable for different type of proteins

√ mAb/Protein
√ BsAb,etc

Fulfill the regulatory requirements

√ Fulfill the regulatory requirements of FDA,EMA and NMPA

High productivity with CHOK1-GenS system

  • High antibody titerHigh antibody titer - average titer: 4.35g/L, up to 8.70g/L

    CHOK1-GenS system
  • Suitable for different type of moleculesSuitable for different type of molecules

    CHOK1-GenS system

Excellent stability with CHOK1-GenS system

  • No. Type Study period T1(g/L) Titer variation
    1 IgG 1 PCB-60days 3.43 -9.90%
    2 IgG 1 PCB-60days 3.54 -7.00%
    3 IgG 4 PCB-50days 3.15 -9.00%
    4 IgG 4 PCB-60days 3.63 -8.20%
    5 IgG 4 PCB-60days 4.23 -10.40%
    6 Bispecific mab PCB-60days 2.72 -3.40%
    7 IgG 1 PCB-60days 4.68 -22.22%
    8 IgG 1 PCB-96days 4.76 -23.39%
    9 Protein PCB-50days 1.91 -11.52%
    10 IgG 1 PCB-60days 6.37 -4.55%
    11 tri-specific ab PCB-50days 0.34 -17.60%
    12 IgG 1 WCB-50days 3.78 -24.60%
    13 IgG 1 WCB-50days 5.74 -20.55%
    • The titer at the end of stability study during fed-batch is recorded as T2.
    • The titer at the beginning of stability study during fed-batch is recorded as T1.
    • Titer variation=(T2-T1)/T1*100%
    • Titer variation should be within 30%.

High productivity with CHOK1-GenS system

  • Titer prior to cell cultureTiter prior to cell culture up to 8.70 g/L

    High productivity with CHOK1-GenS system
  • Excellent Stability in Scale-UpExcellent Stability in Scale-Up from 3L to 200L

    • Excellent Stability in Scale-Up1
    • Excellent Stability in Scale-Up2
    • Excellent Stability in Scale-Up3
    • Excellent Stability in Scale-U3
Delivery Package Delivery items
Host system CHOK1 cell line
Proprietary pGenHT 1.0-DGV vector
Full Traceability Documentation ECACC license agreement and original invoice
Adaptation report
cGMP cell banking report
cGMP cell bank testing report
Vector synthesis report
Vector map and key elements description
Detailed Protocols and Guidance Cell culture protocol
Clone strategy to help construct plasmid correctly
(enzyme cleavage used for gene of interest clone and plasmid linearization)
Cell line development protocol to screen cell clone with the host cell and vector
(including transfection, cell pool screening and cell clone screening)
Technical Support Comprehensive free technical support to ensure your success