Achieve 10-20x higher productivity
Up to 88g/L titer
Perfusion process can help improve the bioprocess efficiency. Compared with fed-batch, perfusion can significantly improve productivity and lower the production cost with smaller footprint and flexibility. Perfusion process is especially suitable for labile and hard-to-express molecules, such as recombinant proteins and multispecific antibodies. There are >20 commercial biologics using perfusion in GMP production.
GenScript ProBio develops a robust, productive and high-quality perfusion process for antibodies and proteins based on ATF, which brings 10-20x higher volumetric productivity. GenScript ProBio not only provides DNA to IND perfusion package, but also helps clients change from fed-batch to perfusion in clinical phase to lower the scale and cost.
Up to 88g/L titer>10x higher productivity
10 Months from DNA to Tox13 Months from DNA to DP ready
Up to 200L perfusion GMP capacityParallelly develop perfusion and fed-batch process
Lower 60%-80% COGS70% CapEx saving
GenScript ProBio developed the intensified perfusion process for a monoclonal antibody molecule. The daily productivity reached 4g/L/day and accumulative productivity reached 88g/L, which was 20x higher than fed-batch process. The product quality remains the same during the cell culture time.