With team of experienced scientists and proprietary development platform, GenScript provides custom services for upstream process development, ranging from optimizing cell growth, screening production media, defining feeding strategies, to studying clone stability, and further scale-up to pilot and commercial production. We also offer a thorough analysis of growth rate, subcultivation ratios, cell mass, and other parameters. Upon request, we can perform additional specific process optimization studies or employ our scaled-down models to predict cell performance.
GenScript offers services for purification process development. For downstream process, protein purification is typically conducted through affinity columns. We also offer other chromatographic methods including gel filtration, ion exchange, and hydrophobic interactions. The purification tags are removed via a specific protease if desired, and the protein is further purified by gel filtration.
10 months from DNA to GMP batch
Multi-dimensional quality tool and comprehensive capability
Guarantee the quality and quantity of sample supply
Risk & Sharing with clients
GenScript is proud of offering its years of demonstrative and professional custom services in generation and selection of stable clones for protein production.
Robust and efficient production processes are crucial to the success of IND-Enabling studies and to the preservation of product competitiveness. GenScript's ‘Time & Quality-Balanced’ process development strategy, including using cell pool samples for purification preliminary development and cell culture process optimization, 3L samples for purification process optimization and formulation development, and 10/50L samples for process scale-up and purification process lock greatly shortens the process development timeline.
GenScript has developed a monoclonal antibody purification platform process that allows clients to quickly establish a production process with an overall recovery rate of around 70% and with acceptable product characteristics, process and product-related impurities. GenScript will customize the processes to meet the unique needs of each client. For example , in the case of biosimilars, GenScript has effective techniques and tools to change the distribution of product glycoforms and charge isomers.
|Chromatography||Filtration and Centrifugation||Virus Inactivation and Clearance|
Determine the Biological Potency of Broad Types of Targets
Cell-based assay Dev. Capability
Different kinds of targets
Platforms for characterization
To request a quotation, please contact us via our toll-free phone, email, fax, or our secure online messaging system. Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.