G Protein-Coupled Receptors (GPCRs) Bioassay Service

• Over 150 GPCR stable cell lines with independent intellectual property

• Over 200 GPCRs bioassay projects delivered

G protein-coupled receptors (GPCRs) play important roles in cellular physiology and they are popular drug targets for various diseases. About 40% of approved drugs on the market belong to this category. Drug candidate screening and profiling is a critical step in GPCR-centered drug discovery. GenScript ProBio offers a comprehensive platform to speed up your GPCR drug discovery.

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Key Features

• Over 150 different GPCR functional cell lines
• Customized GPCR stable cell line construction
• Multiple assay formats including calcium flux, cAMP determination, and Luciferase reporter gene assays
• Determine drug potency and efficacy in agonist, antagonist, inverse agonist and allosteric modulator modes
• Stringent QC standards with competitive prices
• Short turnaround time

More strategies to facilitate new drug development

GenScript ProBio offers multiple functional assays to characterize your samples for agonist, inverse agonist, antagonist and allosteric modulator activities.

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• No.	Part of GPCR cell lines
  1	CHO-K1/ADRA1A
  2	CHO-K1/MC3/Gα15
  3	CHO-K1/ADORA2A/Gα15
  4	1321N1/P2Y1
  5	CHO-K1/5-HT2A
  6	CHO-K1/5-HT2C
  7	1321N1/P2Y12/Gα15
  8	CHO-K1/OPRK1/Gα15
  9	1321N1/P2Y4
  10	1321N1/P2Y11
  11	CHO-K1/OPRM1/Gα15
  12	CHO-K1/OPRD1/Gα15
  13	CHO-K1/ADORA1/Gα15
  14	CHO-K1/ADORA2B/Gα15
  15	CHO-K1/5-HT1A/Gα15
  16	CHO-K1/5-HT4/Gα15
  17	CHO-K1/OPRL1/Gα15
  18	CHO-K1/GLP1/Gα15
  19	CHO-K1/ADORA3/Gα15
  20	CHO-K1 /CXCR1/Gα15

Case Study

GPCR overexpression cell line facilitates new drug development

The expression level of GPCR in vivo is low and the effect of conventional overexpression is not sufficient, which is not conducive to the study of GPCR structure and function. With protein engineering and sequence optimization, we are able to significantly increase the expression level of ADORA2A protein on the cell surface.