• Over 150 GPCR stable cell lines with independent intellectual property
• Over 200 GPCRs bioassay projects delivered
G protein-coupled receptors (GPCRs) play important roles in cellular physiology and they are popular drug targets for various diseases. About 40% of approved drugs on the market belong to this category. Drug candidate screening and profiling is a critical step in GPCR-centered drug discovery. GenScript ProBio offers a comprehensive platform to speed up your GPCR drug discovery.
GenScript ProBio offers multiple functional assays to characterize your samples for agonist, inverse agonist, antagonist and allosteric modulator activities.
GPCR overexpression cell line facilitates new drug development
The expression level of GPCR in vivo is low and the effect of conventional overexpression is not sufficient, which is not conducive to the study of GPCR structure and function. With protein engineering and sequence optimization, we are able to significantly increase the expression level of ADORA2A protein on the cell surface.