Human immune system is regulated by a complex network of inhibitory and stimulatory immune checkpoints that facilitate the elimination of pathogens, while maintaining tolerance to self-antigens. Immune checkpoint receptors perform critical roles in the maintenance of immune homeostasis, but they also have a significant role in cancer progression and autoimmune diseases. Drug discovery targeting immune checkpoint has become hotspot in the field. GenScript ProBio has successfully constructed and validated a series of reporter gene functional cell lines for various immune checkpoints. We have also developed dual target reporter gene cell lines, and established a fast and simple screening platforms for bispecific antibodies including BiTE (Bi-specific T-cell Engager).
Purple：inhibitory immune checkpoints; Orange：co-stimulatory immune checkpoints; Blue: myeloid cell immune checkpoints; Red: bi-specific targeting; Green: targets other than immune checkpoints